Therapeutic Indications and Potential of New Drugs from Cannabinoids
186 The Total Synthesis of Cannabinoids
1 1 -THC (Chart 1 They were usually open, tolerant and
unstructured a poor mans or slaves religion.
Rome considered Christianity to be simply another bothersome
Oriental Mystery Cult, like those of Mithra or Isis, then the most
popular in the Empire.
The Holy Roman Empire
Faced with a crumbling empire, political corruption, and a series of
ruinous wars with barbarians, the old Roman Empire hovered on the
brink of disaster. Zitko-Terris, G THERAPEUTIC INDICATIONS AND POTENTIAL OF NEW DRUGS
As discussed in the Introduction, the main therapeutic indications for L':,1·THC
have emerged from folklore anecdotes in use, and nondrug offenses.
The study then checked the appearance of the names of the members of its sample in
the Narcotics Register, "the most complete file of its type available anywhere in the
United States." Which of these three categories of juvenile offenders was most likely to
turn up in the heroin files later? The data appeared to confirm the progression hypothesis:
"... while half of the male adolescent heroin users had a heroin record five or ten years
later, about forty percent of the marijuana users also acquired a heroin record in this
follow-up period.... marijuana use is almost as portentous of adult heroin use as is actual
use of heroin as an adolescent." The authors strongly qualify the report's findings in their
conclusions; they are in no way guilty of an attempt at an overextension of the
applicability of their results. Of the four groups which the authors point out as most likely
to use marijuana—the slum dweller, the bohemian, the college student, and the high
school student—it is only among the first (and last) of these that the study's data was
likely to be drawn. And it is in this group that the transition to heroin is most likely. In the
other three groups, the use of heroin is certainly far lower than for the urban slum dweller,
so that had the study covered all of the marijuana-using groups, the likelihood of later
heroin use, and therefore of the transition taking place, would have been much smaller.
In fact, the findings are even more narrowly applicable than that. The marijuana smoker
whose use is so conspicuous as to come to the attention of the authorities in no way
represents users as a whole. To come to the attention of any agency of law enforcement is
to be a part of a highly special and unrepresentative kind of social group. Such users are
far more likely to be more highly involved with the drug, to be implicated in some of the
more heavily sanctioned marijuana-related activities, such as selling, and to be incautious.
The Blumer study emphasizes the importance of the cool style in one sector of
marijuana users. This kind of user is inclined to denigrate the delinquency-oriented rowdy,
who is both more likely to become arrested and to move to later addiction. The cool user
is likely to do neither of these. It is almost a certainty that among this conspicuous group,
progression to later heroin use is far more likely than among users as a whole.
The adolescents included in the NACC study are far from representative because they
generally reflect the very highest levels of use. And it is among these levels of use that
later heroin involvement is most likely. It is not unreasonable to assume that less and more
cautious use, lower involvement in the marijuana subculture, and participation in a greater
variety of social groups, will be far less likely to precipitate heroin use and addiction. In
fact, the Narcotics Addiction Control Commission has probably selected the segment o
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Moreover, the nature of the group-character of marijuana use also significantly
determines its impact. Marijuana is not merely smoked in groups, it is smoked in intimate
(15 of 19)4/15/2004 1:03:03 AM
The Marijuana Smokers - Chapter 1
groups. The others with whom one is smoking are overwhelmingly significant others. One
rarely smokes with strangers, with individuals whom one does not care for, or is
indifferent to, or whom one does not expect to like in the future. Even at large parties
where marijuana is smoked, small cliques will form, oases of compatibles, wherein all
share the same activity. Smoking marijuana is symbolic in ways that more accepted
behavior is not; it resembles communal eating in civilizations for whom eating well is a
rare or intermittent festivity. Brotherhood is an element in the marijuana ritual, as is the
notion of sharing something treasured and esteemed. Emphasis is placed on passing a joint
around to all present, completing a circle; this procedure is generally preferred to that of
each participant lighting up his own joint and smoking it by himself, without any group
continuity.25 And, of course, the clandestine nature of the activity, illegal and
underground, lends an air of excitement and collective intrigue to marijuana smoking that
would be absent in a context of licitness, as with drinking.
All of these factors make marijuana use a highly significant and emotionally charged
activity to the participants. These factors, some ideological and some inherent in the
nature of the act itself, conspire to link marijuana smoking to group influences and to
make those who participate in it highly susceptible to the group's definition of
reality—right and wrong, good and bad, true and false.
The case is such that it is not too farfetched to view marijuana use in basically
Durkheimian terms. That is, because of the cultural climate surrounding illicit drug use
and the logistical problems involved (secrecy, the inability to be completely casual about
use, the fact that the safest places to smoke are also the most intimate, etc. ) and the fact
that it is participated with those for whom one has some degree of friendship and emotion,
the activity has strong elements of a tribal ritual: it reaffirms membership in the
subcommunity of users, it recreates symbol and substance of the group, and it relives for
its participants significant meaning, belonging, loyalty. There is even a vigorous
mythology connected with use: tribal lore, a protohistory, an epistemology, a kind of
Marijuana is generally proffered with strong overtones of hospitality. When one person
offers another a smoke of a marijuana cigarette, there is communication taking place
between the two, as the person who offers consciously thinks of sharing and participating
in a common activity. A kind of brotherhood is established in the act. A
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herbalists of chemists of making, using, or giving others any
unguent or preparation including cannabis as medicine or as a
The Mass of the Travesty, which can be likened to the Simpsons,
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Python, or Saturday Night Live
doing irreverent, farcical, or satirical take-offs on the dogmas,
doctrines, indulgences, and rituals of the R.C.Ch. mass andor its
absolute beliefs. ll be better than the street hash you find on the market. Street hash
tends to be made from the less finer skuff material to make more
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you will probably understand why 90% of street hash is sold at rip-off
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Many countries use most of these techniques to make hash.
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GLOSSARY OF TERMS
Acidity: Acidity is Indicated by a pH value Below 7.
Aerate: Loosening or puncturing the soil to increase water penetration.
Afghani: A short Indica land race strain from Afghanistan. Very
Air layering: A specialized method of cloning a plant which is
accomplished by growing new roots from a branch while the branch is
still connected to the parent plant.
Alkaline: Having a pH value of above 7.
Alternate host: One of two kinds of plants on which a parasitic fungus
must develop to complete its life cycle.
Alternate: To be "located directly across from", or it can apply to
stamens when between the petals.
Annual: Completing one life cycle.
Bactericide: A chemical compound that kills or inhibits bacteria.
Bale: Any package of marijuana weighing over 10 lbs.
Ballast: A transformer used mainly with HID lighting equipment.
Bhang: An Indian and Middle Eastern drink made from cannabis.
Biennial: Completing the life cycle in two growing seasons. Cannabis
is not biennial.
Biological Control: Total or partial destruction of pathogen
populations by other organisms.
Blight: Rapid death of a leaf.
Blotch: A disease characterized by large irregular spots on a leaf.
Blue light: Mercury based light or a Metal Halide light.
Blunt: A joint rolled in a tobacco-leaf wrapper.
Bong: A water-cooled pipe made from glass.
Bonsai: The art of growing carefully trained plants.
Bract: A small leaf or scale-like structure associated with and
subtending an inflorescence or cone.
Bud: Female flower.
Caespitose: Growing in tufts.
Calyx: Outer whorl of flowering parts; collective term for all the sepals
of a flower.
Cambium: The thin membrane located just beneath the bark of a plant.
Canker: A canker is a necrotic often sunken area on a stem, trunk, or
branch of a plant.
Cannabinoids: The psychoactive compound found in cannabis.
Chillum: A small fat pipe made of clay.
Chlorophyll: The green pigment in leaves. When present and healthy
usually dominates all other pigments. It is important in the conversion
of CO2 and H2O into glucose.
Chlorosis: Chlorosis is the yellowing of normally green tissues due to
the destruction of the chlorophyll or the partial failure of the
chlorophyll to develop.
Chronic: A strain of cannabis or a high-quality cannabis weed.
Clasping: Leaf partly or wh ?" With both these reagents the
reaction probably proceeds via hydride abstraction but the a-quinone methide
intermediate 143 has also been proposed 1-THC is readily oxidized
to cannabinol on exposure to air Heterocyclic Chem Ben-Zvi,Chem
head cheese seeds
d 2200 PPM overflow water at times
due to laziness and not checking.
"1000mh about 40w/square ft
Took 50 clones and 95% were successful and rooted in about 7 days
Cinderella is a most interesting hybrid.
It was selected/bred for indoor cultivation. It is a short, plant with
The most interesting and handy feature is that you can actually tell the sex when the plant reaches
about 12-14 inches tall. If it is a female, the two telltale pistils are evident at this point.
On my 5 females, I put them on 12/12 when they reached 24 inches. They started flowering by day two and
explode within 10 days. You can harvest in 50 days
They have a fantastically pleasant fruity smell and you can see the resin with 10 days or so. They produce
and excellent yield, require very little time to cut and trim off of the plant when you harvest, and the high is
great. A creative, up high. Puts you in a good mood and gets you doing things. A friend of mine said she
cleaned her whole house and had a good time doing it - You find humor in everything."
"I have only praise for this plant and a tip of the hat to the Brothers Grimm.
Thanks Guys"" -Mr. Worthington
""Nexus> I have a Flat ScrOG that's W=3ft,L=6ft,H=1ft from bottom of plants. My screen is 2 ft from a 1k hps
air-cooled + on a light rail III, Well my question is how violent of a stretcher is c99 and how much of the screen
should I let her fill up? I don't want c99 stretching so much she hits the light and burns."
" =Soul=> I flower my clones at 12"" tall and they end flowering @ 2 ft tall yielding from 1 to 2 ounces dry. Yo
should let the branches grow to 8"" above your screen then switch to 12/12. The final height will be less than 2 ft,
allowing your lamp enough distance from the plants (the light mover HELPS)."
"Nexus> I got 4 c99s and 6 Mr. Nices in the screen growing in a drip/NFT custom made system. I am about 1-2
weeks away from flowering depending on c99? Also how powerful of a yielder is c99, I have heard sooooooo
much spam in the past about her."
"=Soul=>It's easy to be misconstrued as ""spam"" when a strain is getting valid positive feedback as we've seen in
the case of the Cinderella line. It's truly impressive to have combined rapid flowering and hermaphrodite
resistance in a potent, tasty, good-yielding, true strain. That's BOUND to earn some glowing reviews.
To illustrate the yield I'll simply say that a 12"" clone of C99 consistently flowers into a 2-foot tall plant with an
average yield of 1.5 ounces, depending on how densely they're arranged. I have found that 40 clones (10 RW
slabs @ 4 plants per slab) in a 4'x8' area is about optimal. I grow the plants with single colas, or at most, two
main colas. They are supported by using twist-ties to attach each cola to wires running the length of the rows.
This increases yield by forcing the garden into a light-efficient profile.
When you let the colas ""fall all over one
another"" the lIs reported the synthesis of the nitrogen analog 206, which
showed marijuana-like pharmacological profile, Since that time various nitrogen
analogs,H16,107b,119,lZO type 205, 207 to 212 (Chart 4
There are two strains of cannabis cannabis apossativaapos and cannabis aposindicaapos both contain large amounts of thc, but cannabis aposindicaapos contains other cannabinoids such as cbd and cbn. Reserva privada - apollo 13 indica cannabis seeds there are two main varieties of cannabis found in the world cannabis sativa and cannabis indica cannabis sativa the ganja variety - see below right is a large pine-tree like. Accidental proving of cannabis indica cannabis indica lam cannabis indica lam var kafiristanica vavilov cannabis ruderalis janisch cannabis sativa l subsp indica lam e small amp cronquist. Whataposs the difference between cannabis sativa, and cannabis indica outdoor mix 25 graines de cannabis indica 44 early skunk 10 graines de cannabis indica sativa 33 ruderalis skunk 10 graines de cannabis. Cannabis goddess plan pr ntr kmt cannabis indica cannabis sativa cannabis ruderalis thc oil extraction butane honey oil the return of ruderalis by dmt this wild hemp strain, once discarded as. A Bubblegum and Blueberry hybrid. This plant produces larger buds with more strength and taste than original
Bubblegum. Pungent sticky flowers with an overpowering aroma provide the smoker with a bubbly high and long
lasting buzz. Sure makes blowing bowls of bubbles more fun! A super potent Blueberry Indica, coated with a strong concentration of tall standing trichomes. This produces a
long lasting very narcotic experience ~ body high blueberry. Short (80 cm) stout kush plants that produce
dense, tight, rock hard nuggets of trichome coated bud. A true "hash-plant." NK
As a rule if you find a classy seed-bank then you will find
classy breeders using that seed-bank to sell their seeds. If you find a
seed-bank then the first thing you should do is to examine what people
have to say about that seed-bank. The best way to find this out is to
check one of the more popular websites on the net like
or Some web sites give
listings and ratings on seed-banks.
You can also do a search on the net using a search engine like
AltaVista or Yahoo. Find a good web site that is used by a number of
people and not a web site that is used by one person. A community of
users is a good place to go for message board forums and chat. Also
check to see that the site has a registered URL, like a .com site. If they
use a free web site service then consider staying clear of it because it
can disappear without trace overnight. Once you have found a web site
then run a search on 'seeds'. A listing may appear of all known seedbanks
that deal over the Internet. It is best then to check out the
reviews on each seed-bank by the public. A good one is
or . This gives the latest
update on each seed-bank and gives them a review out of 5. Find the
URL of each seed-bank and check out the prices. Some seed-banks do
deals on seeds and you will find that prices do change from bank to
bank. The next thing you do before buying anything is to send the web
master an E-mail. Ask him/her about their services, what seeds you
like, how they delivers, security arrangement, and if they can deliver to
your country. In some countries seeds are legal. In others they are not.
Wait until they give you a reply. If you do not get a reply then do not
use that seed-bank. These people are salesmen and should
communicate with you and answer all your questions. Also ask how
the money should be sent and ask about postage and packaging. Most
seed-banks sell their seeds in batches of 10 - 20. This means that you
will get 10 - 20 seeds in the post. Anything can happen. A misplaced
foot in the postal office can kill the seeds, making them not viable.
Good seed-banks provide good packaging. Ask about it.
If your seeds do not arrive send an E-mail to the seed-bank
and ask them what happened. If they do NOT reply or if your seeds are
lost write them a complaint and then post that complaint in one of the
web boards like yahooka.com. The more people complain the better the
chances of indicating seed-banks that are ripping people off. Also if
you get your seeds in good condition then it is always wise to post a
good review of that seed-bank. This will also improve your
communication with that seed-bank the next time you buy seeds (you
may get discounts). If you do not have access to the web then you will
have to get addresses for these seed-banks and send them a letter
asking for further information. Some seed-banks have even advertised
in the back of this book.
WHAT TO LOOK FOR IN CHOOSING SEEDS
Okay, so now you have an idea of